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(A) Plain x-ray. Bone changes in early osteomyelitis on plain x-rays lag about 2 weeks behind the
infection itself. Acute osteomyelitis must extend at least 1 cm and compromise 30-50% of bone mineral
content to produce noticeable changes on plain x-rays. Changes may not be obvious until 5-7 days from onset in children and 10 to 14 days in adults. On x-rays taken after this time period, regional osteopenia, focal
destructive bony lysis, and periosteal reaction (lifting of the periosteum) may be noted. (B) Computed tomography (CT). CT scanning allows delineation of even the most subtle osseous changes. CT is more sensitive for detection of bony destruction, new bone formation, and periosteal reaction. CT may show these changes earlier than do plain x-ray. CT is unable to demonstrate bone
marrow edema, which means that a normal CT cannot diagnose early osteomyelitis. CT does not
demonstrate adjacent
soft tissue infection. Ct can detect the intramedullary gas, an uncommon but
pathognomonic manifestation of osteomyelitis.
(C) Magnetic resonance imaging (MRI). MRI is the imaging modality of choice for diagnosing
osteomyelitis because of its excellent anatomical detail, high sensitivity for detecting early infection and
lack of ionizing radiation. In addition, MRI is able to identify soft-tissue/joint involvement. Bone marrow edema is the earliest feature of acute osteomyelitis seen
on MRI and can be detected as early as 1-2 days after the onset of infection. The normal marrow has high T1 signal (bright) due to fat within the medulla. In acute osteomyelitis, the bone marrow becomes congested with fluid and pus, producing low
signal (dark) on T1W images and high signal (bright) on T2-weighted images.
(D) Technetium radionuclide bone scan (bone scintigraphy). When plain radiographs are normal
technetium radionuclide bone scan is the standard screening method for the
early evaluation of
osteomyelitis. The patient is injected (usually into a vein) with a small amount of radioactive material such as 600 MBq of technetium-99m-methyl diphosphonate (99mTc-MDP) and then scanned with a
gamma camera, a device sensitive to the radiation emitted by the injected material. The scan is positive
1-2 days after the onset of infection. The affected site demonstrates increased uptake of the radioisotope.